Browsing Toxins By Category
Displaying toxin 1801 - 1825 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D3476 | Albendazole 54965-21-8 | C12H15N3O2S 265.331 g/mol |  |
| Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting it...more Number of Targets: 4 |
| T3D2767 | Mirtazapine 61337-67-5 | C17H19N3 265.353 g/mol |  |
| Mirtazapine acts as an antagonist at central pre-synaptic alpha(2)-receptors, inhibiting negative feedback to the presynaptic nerve and causing an increase in NE relea...more Number of Targets: 23 |
| T3D2696 | Thiamine 59-43-8 | C12H17N4OS 265.354 g/mol |  |
| It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduction in intracellular protein glycation by redirecting the glycolytic ...more Number of Targets: 4 |
| T3D1876 | Nitrosonium (nitrosyl) hexafluoroantimonate 16941-06-3 | F6NOSb 265.760 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D1700 | Chlorothalonil 1897-45-6 | C8Cl4N2 265.911 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 84 |
| T3D0948 | Chlorprocarb 23121-99-5 | C13H18N2O4 266.293 g/mol |  |
| Chlorprocarb is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active sit...more Number of Targets: 2 |
| T3D3723 | Verrucarol 2198-92-7 | C15H22O4 266.333 g/mol |  |
| Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more Number of Targets: 2 |
| T3D3480 | Atenolol 29122-68-7 | C14H22N2O3 266.336 g/mol |  |
| Like metoprolol, atenolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular ...more Number of Targets: 2 |
| T3D0045 | Pentachlorophenol 87-86-5 | C6HCl5O 266.337 g/mol |  |
| Pentachlorophenol is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcho...more Number of Targets: 63 |
| T3D2996 | Desipramine 50-47-5 | C18H22N2 266.381 g/mol |  |
| Desipramine is a tricyclic antidepressant (TCA) that selectively blocks reuptake of norepinephrine (noradrenaline) from the neuronal synapse. It also inhibits serotoni...more Number of Targets: 25 |
| T3D1720 | Aluminium bromide 7727-15-3 | AlBr3 266.694 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 9 |
| T3D2350 | Dichloromethoxydibenzofuran 107819-07-8 | C13H8Cl2O2 267.107 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D0152 | 4,4'-Methylenebis(2-chloroaniline) 101-14-4 | C13H12Cl2N2 267.154 g/mol |  |
| MBOCA's carcinogenicity is thought to be a result of its ability to bind to DNA, hemoglobin, and serum albumin. One metabolite in particular, N-hydroxy-N,N’-diacetyl M...more Number of Targets: 49 |
| T3D1642 | Vanadyl acetylacetonate 3153-26-2 | C10H16O5V 267.173 g/mol |  |
| Vanadium damages alveolar macrophages by decreasing the macrophage membrane integrity, thus impairing the cells' phagocytotic ability and viability. The pentavalent fo...more Number of Targets: 47 |
| T3D0323 | Lead carbonate 598-63-0 | CO3Pb 267.200 g/mol |  |
| Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,...more Number of Targets: 29 |
| T3D4720 | Zidovudine 30516-87-1 | C10H13N5O4 267.241 g/mol |  |
| Zidovudine, a structural analog of thymidine, is a prodrug that must be phosphorylated to its active 5ду_-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). It...more Number of Targets: 1 |
| T3D4275 | Adenosine 58-61-7 | C10H13N5O4 267.241 g/mol |  |
| Adenosine slows conduction time through the AV node and can interrupt the reentry pathways through the AV node, resulting in the restoration of normal sinus rhythm in ...more Number of Targets: 11 |
| T3D0337 | Tetramethyl lead 75-74-1 | C4H12Pb 267.300 g/mol |  |
| Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,...more Number of Targets: 29 |
| T3D0959 | Diethofencarb 87130-20-9 | C14H21NO4 267.321 g/mol |  |
| Diethofencarb is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active si...more Number of Targets: 2 |
| T3D2867 | Apomorphine 41372-20-7 | C17H17NO2 267.322 g/mol |  |
| The precise mechanism of action of apomorphine as a treatment for Parkinson's disease is unknown, although it is believed to be due to stimulation of post-synaptic dop...more Number of Targets: 27 |
| T3D4627 | 7H-Dibenzo[c,g]carbazole 194-59-2 | C20H13N 267.324 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D3684 | Ergine 478-94-4 | C16H17N3O 267.326 g/mol |  |
| Ergoline alkaloids tend to act as a group, producing complex and variable effects of partial agonism or antagonism at adrenergic, dopaminergic, and serotonergic recept...more Number of Targets: 1 |
| T3D2531 | Allopumiliotoxin 73376-38-2 | C16H29NO2 267.407 g/mol |  |
| Allopumiliotoxins may affect sodium and potassium channels in cells and inhibit calcium-dependent ATPase. (L1077, A313, A315) Number of Targets: 11 |
| T3D0676 | Hexamminecobalt(III) chloride 10534-89-1 | Cl3CoH18N6 267.475 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 35 |
| T3D1870 | Dioxygenyl hexafluoroantimonate 12361-66-9 | F6O2Sb 267.750 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |