Browsing Toxins
Displaying toxin 2576 - 2600 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2957 | Balsalazide 80573-04-2 | C17H15N3O6 357.318 g/mol |  |
| The mechanism of action of 5-aminosalicylic acid is unknown, but appears exert its anti-inflammatory effects locally (in the GI tract) rather than systemically. Mucosa...more Number of Targets: 4 |
| T3D2554 | Baclofen 1134-47-0 | C10H12ClNO2 213.661 g/mol |  |
| Baclofen is a direct agonist at GABAB receptors. The precise mechanism of action of Baclofen is not fully known. It is capable of inhibiting both monosynaptic and poly...more Number of Targets: 3 |
| T3D0635 | Azulene 275-51-4 | C10H8 128.171 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 |
| T3D3795 | Azoxystrobin 131860-33-8 | C22H17N3O5 403.388 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 17 |
| T3D1285 | Azocyclotin 41083-11-8 | C20H35N3Sn 436.220 g/mol |  |
| Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local releas...more Number of Targets: 12 |
| T3D4558 | Azelastine 58581-89-8 | C22H24ClN3O 381.898 g/mol |  |
| Azelastine competes with histamine for the H1-receptor sites on effector cells and acts as an antagonist by inhibiting the release of histamine and other mediators inv...more Number of Targets: 7 |
| T3D4799 | Azelaic Acid 123-99-9 | C9H16O4 188.221 g/mol |  |
| The exact mechanism of action of azelaic acid is not known. It is thought that azelaic acid manifests its antibacterial effects by inhibiting the synthesis of cellular...more Number of Targets: 4 |
| T3D4677 | Azathioprine 446-86-6 | C9H7N7O2S 277.263 g/mol |  |
| Azathioprine antagonizes purine metabolism and may inhibit synthesis of DNA, RNA, and proteins. It may also interfere with cellular metabolism and inhibit mitosis. Its...more Number of Targets: 1 |
| T3D2672 | Azaspiracid 214899-21-5 | C47H71NO12 842.066 g/mol |  |
| Azaspiracid-4 dose-dependent inhibits the increase in cytosolic Ca2+ levels induced by thapsigargin (Tg) (A330). Azaspiracid-2 and Azaspiracid-3 clearly increase cytos...more Number of Targets: 1 |
| T3D3794 | Azamethiphos 35575-96-3 | C9H10ClN2O5PS 324.678 g/mol |  |
| Azamethiphos is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholines...more Number of Targets: 11 |
| T3D4676 | Azacitidine 320-67-2 | C8H12N4O5 244.205 g/mol |  |
| Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Azacitidine is thought to induce antineoplastic activity via two mec...more Number of Targets: 3 |
| T3D1042 | Avermectin B1b 65195-56-4 | C47H70O14 859.050 g/mol |  |
| It has low solubility in water and extensive non-specific binding. It opens GABA-insensitive chloride channels, reducing membrane resistance and increasing conductance...more Number of Targets: 11 |
| T3D1041 | Avermectin B1a 65195-55-3 | C48H72O14 873.077 g/mol |  |
| It has low solubility in water and extensive non-specific binding. It opens GABA-insensitive chloride channels, reducing membrane resistance and increasing conductance...more Number of Targets: 11 |
| T3D3751 | Aurovertin D 65256-31-7 | C25H32O9 476.516 g/mol |  |
| Aurovertins are a mixed, noncompetitive inhibitors of both ATP hydrolysis and synthesis. They do this by inhibiting the proton-pumping F1F0-ATP synthase by binding to ...more Number of Targets: 1 |
| T3D3750 | Aurovertin B 55350-03-3 | C25H32O8 460.517 g/mol |  |
| Aurovertins are a mixed, noncompetitive inhibitors of both ATP hydrolysis and synthesis. They do this by inhibiting the proton-pumping F1F0-ATP synthase by binding to ...more Number of Targets: 3 |
| T3D4477 | Atrazine 1912-24-9 | C8H14ClN5 215.683 g/mol |  |
| Not Available Number of Targets: 15 |
| T3D2495 | Atracotoxin, omega- (Hadronyche versuta) 193981-10-1 | Not Available 4055.410 g/mol |  |
| omega-Atracotoxins inhibit invertebrate voltage-gated calcium channel currents. (T170, L1812) Number of Targets: 0 |
| T3D4980 | Atorvastatin 134523-00-5 | C33H34FN2O5 557.632 g/mol |  |
| Atorvastatin selectively and competitively inhibits the hepatic enzyme HMG-CoA reductase. As HMG-CoA reductase is responsible for converting HMG-CoA to mevalonate in t...more Number of Targets: 3 |
| T3D2737 | Atomoxetine 82248-59-7 | C17H21NO 255.355 g/mol |  |
| The precise mechanism by which atomoxetine produces its therapeutic effects in Attention-Deficit/Hyperactivity Disorder (ADHD) is unknown, but is thought to be related...more Number of Targets: 6 |
| T3D3480 | Atenolol 29122-68-7 | C14H22N2O3 266.336 g/mol |  |
| Like metoprolol, atenolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular ...more Number of Targets: 2 |
| T3D4171 | Asymmetric dimethylarginine 30315-93-6 | C8H18N4O2 202.254 g/mol |  |
| Uremic toxins such as asymmetric dimethylarginine are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic ...more Number of Targets: 5 |
| T3D0924 | Asulam, sodium salt 2302-17-2 | C8H10N2NaO4S 253.231 g/mol |  |
| Asulam, sodium salt is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylc...more Number of Targets: 2 |
| T3D0923 | Asulam 3337-71-1 | C8H10N2O4S 230.241 g/mol |  |
| Asulam is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesterase...more Number of Targets: 6 |
| T3D2844 | Astemizole 68844-77-9 | C28H31FN4O 458.570 g/mol |  |
| Astemizole competes with histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. This reversible binding of aste...more Number of Targets: 15 |
| T3D3749 | Asteltoxin 79663-49-3 | C23H30O7 418.480 g/mol |  |
| Asteltoxin inhibits mitochondrial respiration by affecting its energy transfer system. It does this by inhibiting Mg2+ and Na+/K+-ATPases. (A3002, A3003, A3031) Number of Targets: 8 |