Browsing Toxins
Displaying toxin 1301 - 1325 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0025 | P,P'-DDD 72-54-8 | C14H10Cl4 320.041 g/mol |  |
| DDD toxicity occurs via at least four mechanisms, possibly all functioning simultaneously. DDD reduces potassium transport across the membrane. DDD inhibits the inacti...more Number of Targets: 62 |
| T3D0151 | O,P'-DDD 53-19-0 | C14H10Cl4 320.041 g/mol |  |
| DDD toxicity occurs via at least four mechanisms, possibly all functioning simultaneously. DDD reduces potassium transport across the membrane. DDD inhibits the inacti...more Number of Targets: 43 |
| T3D2561 | Chloroquine 54-05-7 | C18H26ClN3 319.872 g/mol |  |
| The mechanism of plasmodicidal action of chloroquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit heme polymerase activity. Th...more Number of Targets: 6 |
| T3D1334 | Lead thiosulfate 26265-65-6 | O3PbS2 319.300 g/mol |  |
| Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,...more Number of Targets: 29 |
| T3D2484 | Tetrodotoxin 4368-28-9 | C11H17N3O8 319.268 g/mol |  |
| Tetrodotoxin binds to what is known as site 1 of the fast voltage-gated sodium channel. Site 1 is located at the extracellular pore opening of the ion channel. The bin...more Number of Targets: 14 |
| T3D4554 | Brompheniramine 86-22-6 | C16H19BrN2 319.239 g/mol |  |
| Brompheniramine works by acting as an antagonist of the H1 histamine receptors. It also functions as a moderately effective anticholingeric agent, likely an antimuscar...more Number of Targets: 6 |
| T3D2667 | Ibandronate 114084-78-5 | C9H23NO7P2 319.229 g/mol |  |
| The action of ibandronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Nitrogen-containing bisphosph...more Number of Targets: 3 |
| T3D0733 | Zinc iodide 10139-47-6 | I2Zn 319.218 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 1 |
| T3D1883 | Sodium thioantimonate(V) 13776-84-6 | Na3S4Sb 318.990 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D2806 | Chlorpromazine 50-53-3 | C17H19ClN2S 318.864 g/mol |  |
| Chlorpromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsych...more Number of Targets: 40 |
| T3D3049 | Clotiazepam 33671-46-4 | C16H15ClN2OS 318.821 g/mol |  |
| Clotiazepam acts at the benzodiazepine receptors (BZD). This agonizes the action of GABA, increasing the frequency of opening of the channel chlorinates and penetratio...more Number of Targets: 18 |
| T3D1352 | Methoxyethelmercuric acetate 151-38-2 | C5H10HgO3 318.720 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 50 |
| T3D0348 | Mercury(II) acetate 1600-27-7 | C4H6HgO4 318.680 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 50 |
| T3D3927 | Tebupirimfos 96182-53-5 | C13H23N2O3PS 318.372 g/mol |  |
| Tebupirimfos is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholines...more Number of Targets: 18 |
| T3D3665 | (S,E)-Zearalenone 17924-92-4 | C18H22O5 318.364 g/mol |  |
| Zearalenone's genotoxicity results from it's ability to cause DNA fragmentation, chromosome aberrations, and DNA adduct formation. It exerts cytotoxic effects by enhan...more Number of Targets: 14 |
| T3D2705 | Fluvoxamine 54739-18-3 | C15H21F3N2O2 318.335 g/mol |  |
| The exact mechanism of action of fluvoxamine has not been fully determined, but appears to be linked to its inhibition of CNS neuronal uptake of serotonin. Fluvoxamine...more Number of Targets: 8 |
| T3D4708 | Phenolphthalein 77-09-8 | C20H14O4 318.323 g/mol |  |
| Not Available Number of Targets: 12 |
| T3D0021 | P,P'-DDE 72-55-9 | C14H8Cl4 318.025 g/mol |  |
| DDE toxicity occurs via at least four mechanisms, possibly all functioning simultaneously. DDE reduces potassium transport across the membrane. DDE inhibits the inacti...more Number of Targets: 60 |
| T3D4549 | Triticonazole 131983-72-7 | C17H20ClN3O 317.813 g/mol |  |
| Not Available Number of Targets: 16 |
| T3D0740 | Zinc pyrithione 13463-41-7 | C10H8N2O2S2Zn 317.722 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 9 |
| T3D3858 | HPTE 2971-36-0 | C14H11Cl3O2 317.595 g/mol |  |
| 2,2-bis(p-hydroxyphenyl)-1,1, 1-trichloroethane (HPTE), acts as an estrogen analogue. HPTE is an estrogen receptor alpha agonist, and also acts as an antagonist at the...more Number of Targets: 29 |
| T3D0135 | Guthion 86-50-0 | C10H12N3O3PS2 317.324 g/mol |  |
| Guthion is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesteras...more Number of Targets: 14 |
| T3D4783 | Nilutamide 63612-50-0 | C12H10F3N3O4 317.221 g/mol |  |
| Nilutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin that stimulate ...more Number of Targets: 4 |
| T3D1874 | Magic acid (fluorosulfuric acid-antimony pentafluoride) 23854-38-8 | F6HO3SSb 316.820 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D2327 | 6-Nitro-1,3,8-trichlorodibenzofuran 125652-17-7 | C12H4Cl3NO3 316.524 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |