Browsing Toxins
Displaying toxin 1876 - 1900 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2696 | Thiamine 59-43-8 | C12H17N4OS 265.354 g/mol |  |
| It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduction in intracellular protein glycation by redirecting the glycolytic ...more Number of Targets: 4 |
| T3D2767 | Mirtazapine 61337-67-5 | C17H19N3 265.353 g/mol |  |
| Mirtazapine acts as an antagonist at central pre-synaptic alpha(2)-receptors, inhibiting negative feedback to the presynaptic nerve and causing an increase in NE relea...more Number of Targets: 23 |
| T3D3476 | Albendazole 54965-21-8 | C12H15N3O2S 265.331 g/mol |  |
| Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting it...more Number of Targets: 4 |
| T3D4520 | Maneb 12427-38-2 | C4H6MnN2S4 265.302 g/mol |  |
| Not Available Number of Targets: 52 |
| T3D2788 | Streptozocin 18883-66-4 | C8H15N3O7 265.221 g/mol |  |
| Streptozotocin is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas. It is used in medical research to prod...more Number of Targets: 3 |
| T3D1359 | Ethylmercury chloride 107-27-7 | C2H5ClHg 265.100 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 51 |
| T3D1307 | Diphenylchlorarsine 712-48-1 | C12H10AsCl 264.582 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 46 |
| T3D3719 | Trichothecolone 2199-06-6 | C15H20O4 264.317 g/mol |  |
| Unlike many other mycotoxins, trichothecenes do not require metabolic activation to exert their biological activity, instead directly reacting with cellular components...more Number of Targets: 2 |
| T3D0354 | Mercury(II) nitrate 10045-94-0 | HHgNO3 263.600 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 59 |
| T3D0355 | Mercury(I) nitrate 10415-75-5 | HHgNO3 263.600 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 59 |
| T3D2818 | Nortriptyline 72-69-5 | C19H21N 263.377 g/mol |  |
| It is believed that nortriptyline either inhibits the reuptake of the neurotransmitter serotonin at the neuronal membrane or acts at beta-adrenergic receptors. Tricycl...more Number of Targets: 24 |
| T3D2759 | Protriptyline 438-60-8 | C19H21N 263.377 g/mol |  |
| Protriptyline acts by decreasing the reuptake of norepinephrine and serotonin (5-HT). Number of Targets: 4 |
| T3D2575 | Tramadol 27203-92-5 | C16H25NO2 263.375 g/mol |  |
| Tramadol and its O-desmethyl metabolite (M1) are selective, weak OP3-receptor agonists. Opiate receptors are coupled with G-protein receptors and function as both posi...more Number of Targets: 9 |
| T3D0936 | Butacarb 2655-19-8 | C16H25NO2 263.375 g/mol |  |
| Butacarb is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active sites o...more Number of Targets: 2 |
| T3D0264 | Methyl parathion 298-00-0 | C8H10NO5PS 263.207 g/mol |  |
| Methyl parathion is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylchol...more Number of Targets: 14 |
| T3D0311 | Roxarsone 121-19-7 | C6H6AsNO6 263.037 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D1877 | Potassium hexahydroxoantimonate(V) 12208-13-8 | H6KO6Sb 262.900 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D0647 | Beryllium iodide 7787-53-3 | BeI2 262.821 g/mol |  |
| Once in the body, beryllium acts as a hapten and interacts with human leucocyte antigen (HLA) DP presenting cells in the lungs, becoming physically associated with a m...more Number of Targets: 3 |
| T3D1673 | Methylene bis(4-cyclohexylisocyanate) 5124-30-1 | C15H22N2O2 262.347 g/mol |  |
| Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more Number of Targets: 39 |
| T3D2803 | Methohexital 151-83-7 | C14H18N2O3 262.304 g/mol |  |
| Methohexital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open....more Number of Targets: 1 |
| T3D0711 | Sodium dichromate 10588-01-9 | Cr2Na2O7 261.968 g/mol |  |
| Hexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produce...more Number of Targets: 5 |
| T3D0768 | Sodium nitroprusside 14402-89-2 | C5FeN6Na2O 261.918 g/mol |  |
| Sodium nitroprusside is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetyl...more Number of Targets: 40 |
| T3D1229 | Copper acetylacetonate 13395-16-9 | C10H14CuO4 261.762 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 6 |
| T3D3060 | Phenindamine 82-88-2 | C19H19N 261.361 g/mol |  |
| Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacolo...more Number of Targets: 1 |
| T3D1115 | Barium nitrate 10022-31-8 | BaN2O6 261.337 g/mol |  |
| Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to...more Number of Targets: 30 |