Browsing Toxins
Displaying toxin 1901 - 1925 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D4516 | Imazapyr 81334-34-1 | C13H15N3O3 261.277 g/mol |  |
| Not Available Number of Targets: 5 |
| T3D0860 | Lotaustralin 534-67-8 | C11H19NO6 261.272 g/mol |  |
| Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more Number of Targets: 38 |
| T3D3801 | Bromacil 314-40-9 | C9H13BrN2O2 261.116 g/mol |  |
| Not Available Number of Targets: 8 |
| T3D4688 | Cyclophosphamide 50-18-0 | C7H15Cl2N2O2P 261.086 g/mol |  |
| Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their atte...more Number of Targets: 2 |
| T3D3513 | Ifosfamide 3778-73-2 | C7H15Cl2N2O2P 261.086 g/mol |  |
| After metabolic activation, active metabolites of ifosfamide alkylate or bind with many intracellular molecular structures, including nucleic acids. The cytotoxic acti...more Number of Targets: 3 |
| T3D0022 | Hexachlorobutadiene 87-68-3 | C4Cl6 260.761 g/mol |  |
| It is believed that intermediates produced by modification of the S- 1,1,2,3,4-pentachlorodienyl cysteine derivative metabolite by gamma-glutamyltransferase are respon...more Number of Targets: 40 |
| T3D1275 | Tin chloride 7646-78-8 | Cl4Sn 260.520 g/mol |  |
| Inorganic and organic tin compounds are weak inhibitors of alcohol dehydrogenase. (A183) Number of Targets: 7 |
| T3D0225 | Phorate 298-02-2 | C7H17O2PS3 260.377 g/mol |  |
| Phorate is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesteras...more Number of Targets: 5 |
| T3D2731 | Ropinirole 91374-21-9 | C16H24N2O 260.375 g/mol |  |
| Ropinirole binds the dopamine receptors D3 and D2. Although the precise mechanism of action of ropinirole as a treatment for Parkinson's disease is unknown, it is beli...more Number of Targets: 18 |
| T3D3491 | Carisoprodol 78-44-4 | C12H24N2O4 260.330 g/mol |  |
| Carisoprodol is a central nervous system depressant that acts as a sedative and skeletal muscle relaxant. Rather than acting directly on skeletal muscle, carisoprodol ...more Number of Targets: 0 |
| T3D0313 | [4-(Aminocarbonyl-amino)phenyl] arsonic acid 121-59-5 | C7H9AsN2O4 260.079 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D0950 | Cloethocarb 51487-69-5 | C11H14ClNO4 259.686 g/mol |  |
| Cloethocarb is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active site...more Number of Targets: 2 |
| T3D1172 | Uranium boride 12007-36-2 | B2U 259.651 g/mol |  |
| Uranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and prot...more Number of Targets: 1 |
| T3D0349 | Mercury(I) acetate 631-60-7 | C2H3HgO2 259.630 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 50 |
| T3D1221 | Copper(II) hydroxide sulfate 1332-03-2 | C17H25NO 259.387 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 6 |
| T3D0701 | Barium chromate 10294-40-3 | BaCrH6O4 259.368 g/mol |  |
| Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to...more Number of Targets: 26 |
| T3D1104 | Barium ferrate 13773-23-4 | C8H10AsNO4 259.091 g/mol |  |
| Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to...more Number of Targets: 21 |
| T3D1882 | Sodium hexafluoroantimonate 16925-25-0 | F6NaSb 258.740 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D1358 | Diethyl mercury 627-44-1 | C4H10Hg 258.710 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 50 |
| T3D3076 | Cicutoxin 505-75-9 | C17H22O2 258.355 g/mol |  |
| Cicutoxin is a cholinergic poison and disrupts the central nervous system. It does this by acting as a non-competitive antagonist at the GABA receptor. (L1232) Number of Targets: 19 |
| T3D3083 | Oenanthotoxin 20311-78-8 | C17H22O2 258.355 g/mol |  |
| Oenanthotoxin is a central nervous system poison and acts as a non-competitive gamma-aminobutyric acid antagonist. (L1243) Number of Targets: 19 |
| T3D3965 | O-Desmethylangolensin 21255-69-6 | C15H14O4 258.269 g/mol |  |
| O-desmethylangolensin (ODMA) exerts androgen receptor antagonistic activity and agonistic activity towards estrogen receptor (ER)-α and ERβ. The structure of ODMA is s...more Number of Targets: 2 |
| T3D3539 | Thalidomide 50-35-1 | C13H10N2O4 258.230 g/mol |  |
| In patients with erythema nodosum leprosum (ENL) the mechanism of action is not fully understood. Available data from in vitro studies and preliminary clinical trials ...more Number of Targets: 10 |
| T3D3727 | Alternariol 641-38-3 | C14H10O5 258.226 g/mol |  |
| Alternariol is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinest...more Number of Targets: 7 |
| T3D1529 | Potassium alum 10043-67-1 | AlKO8S2 258.205 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |