Browsing Toxins
Displaying toxin 1651 - 1675 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D1402 | Cobalt(II) sulfamate 14017-41-5 | CoH4N2O6S2 251.105 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 35 |
| T3D3628 | Quaternium-15 4080-31-3 | C9H16Cl2N4 251.156 g/mol |  |
| Quaternium-15 is a formaldehyde releaser. It is likely that formaldehyde toxicity occurs when intracellular levels saturate formaldehyde dehydrogenase activity, allowi...more Number of Targets: 2 |
| T3D4958 | Deoxyadenosine 958-09-8 | C10H13N5O3 251.242 g/mol |  |
| Not Available Number of Targets: 0 |
| T3D3943 | 2,5-Pyridinedicarboxylic acid, dipropyl ester 136-45-8 | C13H17NO4 251.278 g/mol |  |
| Not known. Number of Targets: 8 |
| T3D4157 | Indican 1336-79-4 | C8H6KNO4S 251.301 g/mol |  |
| Uremic toxins such as indican are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimulate...more Number of Targets: 3 |
| T3D2529 | Pumiliotoxin 73376-35-9 | C16H29NO 251.408 g/mol |  |
| Pumiliotoxin affects voltage-gated calcium channels, interfering with muscle contraction in the heart and skeletal muscle. They also may block sodium and potassium cha...more Number of Targets: 25 |
| T3D1641 | Vanadocene dichloride 12083-48-6 | C10H10Cl2V 252.035 g/mol |  |
| Vanadium damages alveolar macrophages by decreasing the macrophage membrane integrity, thus impairing the cells' phagocytotic ability and viability. The pentavalent fo...more Number of Targets: 47 |
| T3D1174 | Uranium nitride 12033-83-9 | NU 252.036 g/mol |  |
| Uranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and prot...more Number of Targets: 1 |
| T3D0700 | Ammonium dichromate 7789-09-5 | Cr2H8N2O7 252.065 g/mol |  |
| Hexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produce...more Number of Targets: 5 |
| T3D1341 | Mercuric amidochloride 10124-48-8 | ClH2HgN 252.070 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 50 |
| T3D4718 | Uracil mustard 66-75-1 | C8H11Cl2N3O2 252.098 g/mol |  |
| After activation, it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function. Number of Targets: 1 |
| T3D2451 | Orellanine 37338-80-0 | C10H8N2O6 252.180 g/mol |  |
| Bipyridines with charged nitrogen atoms confound important redox reactions in organisms, ‘stealing’ one or two electrons and sometimes bypass the electrons into other ...more Number of Targets: 0 |
| T3D1296 | Arsenic pentachloride 22441-45-8 | AsCl5 252.187 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D4138 | Anatoxin-a(s) 103170-78-1 | C7H17N4O4P 252.208 g/mol |  |
| Anatoxin-a(s) is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholine...more Number of Targets: 0 |
| T3D2887 | Oxcarbazepine 28721-07-5 | C15H12N2O2 252.268 g/mol |  |
| The exact mechanism by which oxcarbazepine exerts its anticonvulsant effect is unknown. It is known that the pharmacological activity of oxcarbazepine occurs primarily...more Number of Targets: 1 |
| T3D2728 | Phenytoin 57-41-0 | C15H12N2O2 252.268 g/mol |  |
| Phenytoin acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. By promoting sodium efflux f...more Number of Targets: 10 |
| T3D0009 | Benzo[a]pyrene 50-32-8 | C20H12 252.309 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 9 |
| T3D0010 | Benzo[b]fluoranthene 205-99-2 | C20H12 252.309 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 5 |
| T3D0062 | Benzo[k]fluoranthene 207-08-9 | C20H12 252.309 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 |
| T3D0070 | Benzofluoranthene 56832-73-6 | C20H12 252.309 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 |
| T3D0622 | Benzo[j]fluoranthene 205-82-3 | C20H12 252.309 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 |
| T3D0226 | Benzo[e]pyrene 192-97-2 | C20H12 252.309 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 |
| T3D3857 | Hexazinone 51235-04-2 | C12H20N4O2 252.313 g/mol |  |
| Not Available Number of Targets: 4 |
| T3D2810 | Cimetidine 51481-61-9 | C10H16N6S 252.339 g/mol |  |
| Cimetidine binds to an H2-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in...more Number of Targets: 5 |
| T3D0363 | Mercury(II) cyanide 592-04-1 | C2HgN2 252.620 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 91 |