Browsing Toxins
Displaying toxin 1201 - 1225 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D3086 | Strychnine 57-24-9 | C21H22N2O2 334.412 g/mol |  |
| Strychnine acts as an antagonist at the inhibitory or strychnine-sensitive glycine receptor, a ligand-gated chloride channel in the spinal cord and the brain. (L1230) Number of Targets: 8 |
| T3D3085 | Capsaicin 404-86-4 | C18H27NO3 305.412 g/mol |  |
| The burning and painful sensations associated with capsaicin result from its chemical interaction with sensory neurons. Capsaicin, as a member of the vanilloid family,...more Number of Targets: 5 |
| T3D3084 | Resiniferatoxin 57444-62-9 | C37H40O9 628.708 g/mol |  |
| Resiniferatoxin activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception (the transmission of physiological pain...more Number of Targets: 1 |
| T3D3083 | Oenanthotoxin 20311-78-8 | C17H22O2 258.355 g/mol |  |
| Oenanthotoxin is a central nervous system poison and acts as a non-competitive gamma-aminobutyric acid antagonist. (L1243) Number of Targets: 19 |
| T3D3082 | beta-Methylamino-L-alanine 15920-93-1 | C4H10N2O2 118.134 g/mol |  |
| BMAA may cause neurotoxic effects by damaging cells (such as neurons) in the motor cortex and spinal cord. (L1241) Number of Targets: 0 |
| T3D3081 | (-)-Gossypol 90141-22-3 | C30H30O8 518.554 g/mol |  |
| Gossypol may cause apoptosis via the regulation of Bax and Bcl-2 proteins. It is also an inhibitor of calcineurin and protein kinases C, and has been shown to bind cal...more Number of Targets: 23 |
| T3D3079 | Djenkolic acid 498-59-9 | C7H14N2O4S2 254.327 g/mol |  |
| The toxicity of djenkolic acid in humans arises from its poor solubility under acidic conditions after consumption of the jenkol bean. The amino acid precipitates into...more Number of Targets: 0 |
| T3D3078 | Aconitine 302-27-2 | C34H47NO11 645.737 g/mol |  |
| Aconitine opens voltage-gated sodium channed in the heart and other tissues. (L1235) Number of Targets: 14 |
| T3D3077 | Delphinine 561-07-9 | C33H45NO9 599.712 g/mol |  |
| Delphinine acts as an allosteric modulator of voltage-gated sodium channels. (L1234) Number of Targets: 14 |
| T3D3076 | Cicutoxin 505-75-9 | C17H22O2 258.355 g/mol |  |
| Cicutoxin is a cholinergic poison and disrupts the central nervous system. It does this by acting as a non-competitive antagonist at the GABA receptor. (L1232) Number of Targets: 19 |
| T3D3075 | Brucine 357-57-3 | C23H26N2O4 394.464 g/mol |  |
| Brucine acts as an antagonist at the inhibitory or strychnine-sensitive glycine receptor, a ligand-gated chloride channel in the spinal cord and the brain. (L1230) Number of Targets: 9 |
| T3D3074 | Anisatin 5230-87-5 | C15H20O8 328.315 g/mol |  |
| Anisatin acts as a GABA system antagonist. It binds non-competitively to the picrotoxinin site of the GABA receptor, prolonging the closed time of the receptor channel...more Number of Targets: 19 |
| T3D3073 | Abrin-d 1393-62-0 | Not Available 58869.605 g/mol |  |
| Abrin works by penetrating the cells of the body and inhibiting cell protein synthesis. By attaching to a carbohydrate chain on the cell surface, the abrin molecule an...more Number of Targets: 1 |
| T3D3072 | Abrin-c 53597-24-3 | Not Available 62817.245 g/mol |  |
| Abrin works by penetrating the cells of the body and inhibiting cell protein synthesis. By attaching to a carbohydrate chain on the cell surface, the abrin molecule an...more Number of Targets: 1 |
| T3D3071 | Abrin-b Not Available | Not Available 59114.060 g/mol |  |
| Abrin works by penetrating the cells of the body and inhibiting cell protein synthesis. By attaching to a carbohydrate chain on the cell surface, the abrin molecule an...more Number of Targets: 1 |
| T3D3070 | Abrin-a 53597-23-2 | Not Available 59243.125 g/mol |  |
| Abrin works by penetrating the cells of the body and inhibiting cell protein synthesis. By attaching to a carbohydrate chain on the cell surface, the abrin molecule an...more Number of Targets: 1 |
| T3D3069 | Methsuximide 77-41-8 | C12H13NO2 203.237 g/mol |  |
| Methsuximide suppresses the paroxysmal three cycle per second spike and wave activity associated with lapses of consciousness which is common in absence (petit mal) se...more Number of Targets: 1 |
| T3D3068 | Silver sulfadiazine 22199-08-2 | C10H9AgN4O2S 357.137 g/mol |  |
| Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulf...more Number of Targets: 1 |
| T3D3067 | Vapreotide 103222-11-3 | C57H70N12O9S2 1131.371 g/mol |  |
| The exact mechanism of action is unknown, although one study has provided in vitro and in vivo evidence for a tachykinin NK1 receptor antagonist effect in the analgesi...more Number of Targets: 3 |
| T3D3066 | Bepotastine 125602-71-3 | C21H25ClN2O3 388.888 g/mol |  |
| Because of a type 1 hypersensitivity reaction cascade that is triggered by antigen exposure, allergic conjunctivitis occurs. Allergen exposure is followed by conjuncti...more Number of Targets: 1 |
| T3D3064 | Chlophedianol 791-35-5 | C17H20ClNO 289.800 g/mol |  |
| Suppresses the cough reflex by a direct effect on the cough center in the medulla of the brain. Number of Targets: 1 |
| T3D3063 | Quinestrol 152-43-2 | C25H32O2 364.520 g/mol |  |
| Estrogens diffuse into their target cells and interact with a protein receptor (the estrogen receptor). Estrogen interacts with a target cell receptor. When the estrog...more Number of Targets: 1 |
| T3D3062 | Calcipotriol 112965-21-6 | C27H40O3 412.605 g/mol |  |
| The precise mechanism of calcipotriol in remitting psoriasis is not well-understood. However, it has been shown to have comparable affinity with calcitriol for the Vit...more Number of Targets: 1 |
| T3D3060 | Phenindamine 82-88-2 | C19H19N 261.361 g/mol |  |
| Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacolo...more Number of Targets: 1 |
| T3D3057 | Nitrazepam 146-22-5 | C15H11N3O3 281.266 g/mol |  |
| Nitrazepam belongs to a group of medicines called benzodiazepines. It acts on benzodiazepine receptors in the brain which are associated with the GABA receptors causin...more Number of Targets: 24 |