Browsing Toxins
Displaying toxin 1276 - 1300 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2991 | Ambenonium 7648-98-8 | C28H42Cl2N4O2 537.564 g/mol |  |
| Ambenonium is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholineste...more Number of Targets: 1 |
| T3D2990 | Phenacemide 63-98-9 | C9H10N2O2 178.188 g/mol |  |
| Phenacemide binds to and blocks neuronal sodium channels or voltage sensitive calcium channels. This blocks or suppresses neuronal depolarization and hypersynchronizat...more Number of Targets: 1 |
| T3D2989 | Chlorpheniramine 132-22-9 | C16H19ClN2 274.788 g/mol |  |
| Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative sympt...more Number of Targets: 13 |
| T3D2988 | Miconazole 22916-47-8 | C18H14Cl4N2O 416.129 g/mol |  |
| Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fun...more Number of Targets: 17 |
| T3D2987 | Methyprylon 125-64-4 | C10H17NO2 183.248 g/mol |  |
| Methyprylon binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. ...more Number of Targets: 2 |
| T3D2986 | Sibutramine 106650-56-0 | C17H26ClN 279.848 g/mol |  |
| Sibutramine produces its therapeutic effects by inhibition of norepinephrine (NE), serotonin (5-hydroxytryptamine, 5-HT), and to a lesser extent, dopamine reuptake at ...more Number of Targets: 6 |
| T3D2985 | Sertraline 79617-96-2 | C17H17Cl2N 306.230 g/mol |  |
| The exact mechanism of action sertraline is not fully known, but the drug appears to selectively inhibit the reuptake of serotonin at the presynaptic membrane. This re...more Number of Targets: 9 |
| T3D2984 | Pimozide 2062-78-4 | C28H29F2N3O 461.546 g/mol |  |
| The ability of pimozide to suppress motor and phonic tics in Tourette's Disorder is thought to be primarily a function of its dopaminergic blocking activity. Pimozide ...more Number of Targets: 18 |
| T3D2983 | Flucytosine 2022-85-7 | C4H4FN3O 129.093 g/mol |  |
| Although the exact mode of action is unknown, it has been proposed that flucytosine acts directly on fungal organisms by competitive inhibition of purine and pyrimidin...more Number of Targets: 2 |
| T3D2982 | Dimethyl sulfoxide 67-68-5 | C2H6OS 78.133 g/mol |  |
| The mechanism of dimethyl sulfoxide's actions is not well understood. Dimethyl sulfoxide has demonstrated antioxidant activity in certain biological settings. For exam...more Number of Targets: 14 |
| T3D2980 | Benzocaine 94-09-7 | C9H11NO2 165.189 g/mol |  |
| Benzocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal mem...more Number of Targets: 3 |
| T3D2979 | Pilocarpine 54-71-7 | C11H16N2O2 208.257 g/mol |  |
| Pilocarpine is a cholinergic parasympathomimetic agent. It increase secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary...more Number of Targets: 4 |
| T3D2978 | Diphenoxylate 915-30-0 | C30H32N2O2 452.587 g/mol |  |
| Diphenoxylate is an opiate receptor agonists that stimulate mu receptors in GI to decrease the peristalsis and constrict the sphincters. Diphenoxylate has a direct eff...more Number of Targets: 3 |
| T3D2977 | Vigabatrin 60643-86-9 | C6H11NO2 129.157 g/mol |  |
| Vigabatrin increases brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by irreversibly inhibiting enzymes that catabol...more Number of Targets: 2 |
| T3D2976 | Diphenhydramine 58-73-1 | C17H21NO 255.355 g/mol |  |
| Diphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the...more Number of Targets: 8 |
| T3D2975 | Perhexiline 6621-47-2 | C19H35N 277.488 g/mol |  |
| Perhexiline binds to the mitochondrial enzyme carnitine palmitoyltransferase (CPT)-1 and CPT-2. It acts by shifting myocardial substrate utilisation from long chain fa...more Number of Targets: 4 |
| T3D2974 | Dihydrotachysterol 67-96-9 | C28H46O 398.664 g/mol |  |
| Once hydroxylated to 25-hydroxydihydrotachysterol, the modified drug binds to the vitamin D receptor. The bound form of the vitamin D receptor serves as a transcriptio...more Number of Targets: 1 |
| T3D2973 | Clonazepam 1622-61-3 | C15H10ClN3O3 315.711 g/mol |  |
| Allosteric interactions between central benzodiazepine receptors and gamma-aminobutyric acid (GABA) receptors potentiate the effects of GABA. As GABA is an inhibitory ...more Number of Targets: 21 |
| T3D2972 | Melatonin 73-31-4 | C13H16N2O2 232.278 g/mol |  |
| Melatonin is a derivative of tryptophan. It binds to melatonin receptor type 1A, which then acts on adenylate cylcase and the inhibition of a cAMP signal transduction ...more Number of Targets: 18 |
| T3D2970 | Ibuprofen 15687-27-1 | C13H18O2 206.281 g/mol |  |
| The exact mechanism of action of ibuprofen is unknown. Ibuprofen is a non-selective inhibitor of cyclooxygenase, an enzyme invovled in prostaglandin synthesis via the ...more Number of Targets: 15 |
| T3D2969 | Rifampin 13292-46-1 | C43H58N4O12 822.940 g/mol |  |
| Rifampin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death. Number of Targets: 10 |
| T3D2968 | Gatifloxacin 112811-59-3 | C19H22FN3O4 375.394 g/mol |  |
| The bactericidal action of Gatifloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA...more Number of Targets: 3 |
| T3D2967 | Memantine 19982-08-2 | C12H21N 179.302 g/mol |  |
| Memantine exerts its action through uncompetitive NMDA receptor antagonism, binding preferentially to the NMDA receptor-operated cation channels. Prolonged increased l...more Number of Targets: 8 |
| T3D2966 | Carphenazine 2622-30-2 | C23H29N3O2S 411.560 g/mol |  |
| A yellow, powdered, phenothiazine antipsychotic agent used in the treatment of acute or chronic schizophrenia. The term "phenothiazines" is used to describe the larges...more Number of Targets: 3 |
| T3D2965 | Selegiline 14611-51-9 | C13H17N 187.281 g/mol |  |
| Although the mechanisms for selegiline's beneficial action in the treatment of Parkinson's disease are not fully understood, the selective, irreversible inhibition of ...more Number of Targets: 4 |